Impact of Cytochromes P450 3A4 and 2B6 gene polymorphisms on predisposition and prognosis of acute myeloid leukemia: an Egyptian case-control study

Abstract Background It has been postulated that the interaction between environmental risk factors and genetic susceptibility is a possible cause for development of acute myeloid leukemia (AML). Cytochrome P450 (CYP) detoxification enzymes are responsible elimination oxidative stress. Genetic polymorphisms in these may AML due to enhanced accumulation reactive oxygen species. To study association CYP3A4 (A290G) CYP2B6 (G516T) gene predisposition prognosis AML, 50 upfront patients healthy individuals were genotyped single-nucleotide (SNPs) using polymerase chain reaction (PCR)-based restriction fragment length polymorphism (RFLP) technique. The evaluated relation response chemotherapy survival. Results mutation carries threefold developing (odds ratio [OR], 3.0; 95% confidence interval [CI], 1.3–6.9), whereas approximately fourfold (OR, 3.8; CI, 1.4–10.1). presence combined conferred about 15-fold increased compared with single 14.8; 1.8–124.2). associated worse overall survival ( P = 0.030). Conclusion CYP enzyme AML. Elimination stress genetically susceptible decrease improve